By Patrice McCoy
When you first hear the term liposome, the preliminary questions that crop up include what it is and what it does. The reason why you are reading about this tiny, liquid-filled bubble is that it has several health benefits and usages, many of which we are not aware of. However, let us understand the basics of this mostly-unknown entity before we proceed with its properties and benefits.
Discovered more by chance than by choice, it was born when a hematologist researcher was experimenting an electron microscope in his lab in Cambridge in the United Kingdom, when he chanced upon this molecule. The discovery of this molecule also coincided with yet another important finding - the human cell wall was bi layered. The name is a combination of two Greek words Lipos means fat and soma means body.
Liposome is thus a tiny molecule that looks like a bubble and is filled with fluids. It has two layers made of phospholipids which are also found in cellular walls. It is primarily used to deliver drugs and essential nutrients, to be transported directly into the blood and the cells of the body. This delivery technique is more efficient than any known classical delivery method.
The phospholipid layers are the biggest contributors to the overall functional efficacy of the molecule. The inside of the layer is water soluble whereas the outer surface is not attracted to water as it is made of fatty substances. Thus when the molecule comes in contact with water, it immediately forms a globe around it. While the water-soluble substances get together in the water-friendly side, the fat-soluble substances gather on the other side. This is the basic mode of action of the molecule in delivering drugs and nutrients into the blood stream.
The mode of action of this microscopic molecule is also beneficial in terms of increased absorption by the body. When the problem is related to lack of adequate nutrition, or poor absorption ability due to normal dimensions of a molecule, such enhanced delivery systems can improve the efficacy of the therapy. While the average absorption rate of normal-size molecules hovers around 3 to 5 percent, absorption of this miniscule molecule shoots up to 90 percent.
The section which carries the fatty substances also has its own health benefits. Because it is rich in lecithin and other important oils, the cells simply love welcoming it. The cells need to quickly replenish damaged cells as well as maintain its health. The cells also need it for building fresh cell membranes. Nothing is as good as these fatty nutrients.
Foods that are rich in trans fats normally cause imbalance of phospholipids which make up for 50 percent of the cell membranes. This impaired functioning of the cells impedes entry of oxygen and other cellular nutrients. It also creates problems in waste elimination from within the cell space
Delivery of drugs and nutrients at the right time and in the quickest manner possible is mandatory for managing critical illnesses. The liposome molecule makes this task easier. Also called the liposomal delivery the molecule helps in the transmission of a lot of important life-saving medicines and nutrients to critically ill patients suffering from Parkinson disease, autism, congestive heart failure and more.
Discovered more by chance than by choice, it was born when a hematologist researcher was experimenting an electron microscope in his lab in Cambridge in the United Kingdom, when he chanced upon this molecule. The discovery of this molecule also coincided with yet another important finding - the human cell wall was bi layered. The name is a combination of two Greek words Lipos means fat and soma means body.
Liposome is thus a tiny molecule that looks like a bubble and is filled with fluids. It has two layers made of phospholipids which are also found in cellular walls. It is primarily used to deliver drugs and essential nutrients, to be transported directly into the blood and the cells of the body. This delivery technique is more efficient than any known classical delivery method.
The phospholipid layers are the biggest contributors to the overall functional efficacy of the molecule. The inside of the layer is water soluble whereas the outer surface is not attracted to water as it is made of fatty substances. Thus when the molecule comes in contact with water, it immediately forms a globe around it. While the water-soluble substances get together in the water-friendly side, the fat-soluble substances gather on the other side. This is the basic mode of action of the molecule in delivering drugs and nutrients into the blood stream.
The mode of action of this microscopic molecule is also beneficial in terms of increased absorption by the body. When the problem is related to lack of adequate nutrition, or poor absorption ability due to normal dimensions of a molecule, such enhanced delivery systems can improve the efficacy of the therapy. While the average absorption rate of normal-size molecules hovers around 3 to 5 percent, absorption of this miniscule molecule shoots up to 90 percent.
The section which carries the fatty substances also has its own health benefits. Because it is rich in lecithin and other important oils, the cells simply love welcoming it. The cells need to quickly replenish damaged cells as well as maintain its health. The cells also need it for building fresh cell membranes. Nothing is as good as these fatty nutrients.
Foods that are rich in trans fats normally cause imbalance of phospholipids which make up for 50 percent of the cell membranes. This impaired functioning of the cells impedes entry of oxygen and other cellular nutrients. It also creates problems in waste elimination from within the cell space
Delivery of drugs and nutrients at the right time and in the quickest manner possible is mandatory for managing critical illnesses. The liposome molecule makes this task easier. Also called the liposomal delivery the molecule helps in the transmission of a lot of important life-saving medicines and nutrients to critically ill patients suffering from Parkinson disease, autism, congestive heart failure and more.
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